2002 287(3):321–8.Ĭolon Cancer Laparoscopic or Open Resection Study G, Buunen M, Veldkamp R, Hop WC, Kuhry E, Jeekel J, et al.

Short-term quality-of-life outcomes following laparoscopic-assisted colectomy vs open colectomy for colon cancer: a randomized trial. Weeks JC, Nelson H, Gelber S, Sargent D, Schroeder G, Clinical Outcomes of Surgical Therapy Study G. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial.

Veldkamp R, Kuhry E, Hop WC, Jeekel J, Kazemier G, Bonjer HJ, et al. Short term benefits for laparoscopic colorectal resection. Schwenk W, Haase O, Neudecker J, Muller JM. Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Leung KL, Kwok SP, Lam SC, Lee JF, Yiu RY, Ng SS, et al. Short-term costs of conventional vs laparoscopic assisted surgery in patients with colorectal cancer (MRC CLASICC trial). 2004 350(20):2050–9.įranks PJ, Bosanquet N, Thorpe H, Brown JM, Copeland J, Smith AM, et al. A comparison of laparoscopically assisted and open colectomy for colon cancer.

However, the microbial imbalance, in addition to the reduction in organic acids, could be improved by perioperative synbiotics treatment.Ĭlinical Outcomes of Surgical Therapy Study G. The efficacy of perioperative administration of synbiotics was not validated as a treatment for reducing the incidence of infectious complications after laparoscopic colorectal resection.

Synbiotics treatment reversed the changes in fecal bacteria and organic acids after surgery and suppressed the increases in potentially pathogenic species, such as Clostridium difficile. Overall, the rate of postoperative complications, including anastomotic leakage, did not differ significantly between the two groups. In this study, 379 patients were enrolled and randomly assigned (173 to the synbiotics group and 206 to the control group), of whom 362 patients (168 to the synbiotics group and 194 to the control group) were eligible for this study. The primary study outcome was the development of infectious complications, particularly surgical site infection (SSI), within 30 days of surgery. In this single-center randomized, controlled trial, patients scheduled to undergo elective laparoscopic colorectal surgery were eligible to participate and randomly assigned to a synbiotics group or a control group. The aim of this study was to assess the effect of perioperative oral administration of synbiotics on the surgical outcome in patients undergoing laparoscopic colorectal resection.

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